Assay Detail
Binding
CHEMBL3106115
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+)Pentazocine from sigma 1 receptor (unknown origin)
7
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.91 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 2 | 8.92 |
| CHEMBL3104093 | — | — | 2 | 6.66 |
| CHEMBL3104091 | — | — | 2 | 5.21 |
| CHEMBL3104092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.66 | nM | 8.78 |
| CHEMBL3104093 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL3104093 | — | Ki | = | 218.78 | nM | 6.66 |
| CHEMBL3104091 | — | Ki | = | 6143.0 | nM | 5.21 |
| CHEMBL3104091 | — | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL3104092 | — | Ki | > | 10000.0 | nM | - |