Assay Detail
Functional
CHEMBL3107538
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ex vivo vasorelaxant activity in Wistar rat endothelium thoracic aortic ring assessed as reduction of KCl-induced contraction
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.64 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103831 | NAPROXCINOD | 3.0 | 1 | 6.33 |
| CHEMBL3104555 | — | — | 1 | 5.78 |
| CHEMBL3104550 | — | — | 1 | 5.38 |
| CHEMBL3104549 | — | — | 1 | 5.38 |
| CHEMBL3104556 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103831 | NAPROXCINOD | IC50 | = | 467.74 | nM | 6.33 |
| CHEMBL3104555 | — | IC50 | = | 1659.59 | nM | 5.78 |
| CHEMBL3104550 | — | IC50 | = | 4168.69 | nM | 5.38 |
| CHEMBL3104549 | — | IC50 | = | 4168.69 | nM | 5.38 |
| CHEMBL3104556 | — | IC50 | = | 4897.79 | nM | 5.31 |