Compound Detail
CHEMBL2103831
NAPROXCINOD 🧪 Phase III
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL2103831 |
| Name | NAPROXCINOD |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | AKFJWRDCWYYTIG-ZDUSSCGKSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
9
Known Names
5
Indications
1
Mechanisms
Molecular Properties
347.4
MW (Da)
3.48
ALogP
6
HBA
0
HBD
87.9
PSA (Ų)
0.30
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Cyclooxygenase inhibitor | INHIBITOR | Cyclooxygenase | ✓ | ✓ |
Indications
Osteoarthritis Osteoarthritis, Hip Rheumatic Diseases Liver Diseases Renal Insufficiency
ATC Classification
M01AE18
naproxcinod
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
Activity Summary
IC50 2 meas. best 6.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thoracic aorta CHEMBL2367449 | IC50 | 6.33 | 6.33 | 467.7 | 1 |
| Molecular identity unknown CHEMBL612546 | IC50 | 5.28 | 5.28 | 5248.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thoracic aorta | IC50 | = | 467.74 | nM | 6.33 | Ex vivo vasorelaxant activity in Wistar rat endothelium thoracic aortic ring ass... | 24373735 |
| Molecular identity unknown | IC50 | = | 5248.07 | nM | 5.28 | Vasorelaxing effect in Wistar rat thoracic aorta ring assessed as reduction of K... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24373735 | 10.1016/j.bmc.2013.12.008 | Liver | 6 |
| 24373735 | 10.1016/j.bmc.2013.12.008 | Thoracic aorta | 3 |
| 33168231 | 10.1016/j.ejmech.2020.112983 | Liver | 2 |
Data from ChEMBL 36 via Core Engine