Assay Detail
Functional
CHEMBL3880993
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasorelaxing effect in Wistar rat thoracic aorta ring assessed as reduction of KCl-induced contractile tone
29
Total Activities
29
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
1,5-Diaryl-2-alkylpyrrole-3-Substituted Nitro Esters, Selective COX-2 Inhibitors and Nitric Oxide Donors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.80 | 6.79 |
| pIC50 | 13 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1939671 | — | — | 1 | 6.79 |
| CHEMBL1939676 | — | — | 1 | 6.75 |
| CHEMBL1939670 | — | — | 1 | 6.48 |
| CHEMBL1939674 | — | — | 1 | 6.34 |
| CHEMBL3104553 | — | — | 1 | 5.95 |
| CHEMBL3969299 | — | — | 1 | 5.95 |
| CHEMBL1939668 | — | — | 1 | 5.85 |
| CHEMBL2153827 | — | — | 1 | 5.81 |
| CHEMBL2153825 | — | — | 1 | 5.66 |
| CHEMBL1939672 | — | — | 1 | 5.46 |
| CHEMBL3905421 | — | — | 1 | 5.40 |
| CHEMBL2337401 | — | — | 1 | 5.32 |
| CHEMBL3104556 | — | — | 1 | 5.31 |
| CHEMBL3927500 | — | — | 1 | 5.30 |
| CHEMBL2103831 | NAPROXCINOD | 3.0 | 1 | 5.28 |
| CHEMBL2337400 | — | — | 1 | 5.22 |
| CHEMBL1939677 | — | — | 1 | - |
| CHEMBL1939675 | — | — | 1 | - |
| CHEMBL3938915 | — | — | 1 | - |
| CHEMBL3900449 | — | — | 1 | - |
| CHEMBL3104544 | — | — | 1 | - |
| CHEMBL3104542 | — | — | 1 | - |
| CHEMBL2337402 | — | — | 1 | - |
| CHEMBL3942961 | — | — | 1 | - |
| CHEMBL2337403 | — | — | 1 | - |
| CHEMBL2337404 | — | — | 1 | - |
| CHEMBL2337406 | — | — | 1 | - |
| CHEMBL2337405 | — | — | 1 | - |
| CHEMBL3908211 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1939671 | — | IC50 | = | 162.18 | nM | 6.79 |
| CHEMBL1939676 | — | IC50 | = | 177.83 | nM | 6.75 |
| CHEMBL1939670 | — | IC50 | = | 331.13 | nM | 6.48 |
| CHEMBL1939674 | — | IC50 | = | 457.09 | nM | 6.34 |
| CHEMBL3104553 | — | IC50 | = | 1122.02 | nM | 5.95 |
| CHEMBL3969299 | — | IC50 | = | 1122.02 | nM | 5.95 |
| CHEMBL1939668 | — | IC50 | = | 1412.54 | nM | 5.85 |
| CHEMBL2153827 | — | IC50 | = | 1548.82 | nM | 5.81 |
| CHEMBL2153825 | — | IC50 | = | 2187.76 | nM | 5.66 |
| CHEMBL1939672 | — | IC50 | = | 3467.37 | nM | 5.46 |
| CHEMBL3905421 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL2337401 | — | IC50 | = | 4786.3 | nM | 5.32 |
| CHEMBL3104556 | — | IC50 | = | 4897.79 | nM | 5.31 |
| CHEMBL3927500 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL2103831 | NAPROXCINOD | IC50 | = | 5248.07 | nM | 5.28 |
| CHEMBL2337400 | — | IC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL1939677 | — | pIC50 | - | — | - | |
| CHEMBL1939675 | — | pIC50 | - | — | - | |
| CHEMBL3938915 | — | pIC50 | - | — | - | |
| CHEMBL3900449 | — | pIC50 | - | — | - | |
| CHEMBL3104544 | — | pIC50 | - | — | - | |
| CHEMBL3104542 | — | pIC50 | - | — | - | |
| CHEMBL2337402 | — | pIC50 | - | — | - | |
| CHEMBL3942961 | — | pIC50 | - | — | - | |
| CHEMBL2337403 | — | pIC50 | - | — | - | |
| CHEMBL2337404 | — | pIC50 | - | — | - | |
| CHEMBL2337406 | — | pIC50 | - | — | - | |
| CHEMBL2337405 | — | pIC50 | - | — | - | |
| CHEMBL3908211 | — | pIC50 | - | — | - |