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Compound Detail

CHEMBL3969299

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Cc1c(CC(=O)OCC(CO[N+](=O)[O-])O[N+](=O)[O-])cc(-c2ccc(S(C)(=O)=O)cc2)n1-c1ccccc1

Basic Information

ChEMBL ID CHEMBL3969299
Phase Preclinical
Structure Type MOL
InChI Key UDGRTYSIHIRFEK-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

533.5
MW (Da)
2.73
ALogP
11
HBA
0
HBD
170.1
PSA (Ų)
0.19
QED
2
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H23N3O10S
MW 533.52
Aromatic Rings 3
Heavy Atoms 37
NP-Likeness -0.73

Activity Summary

IC50 1 meas. best 5.95

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Molecular identity unknown
CHEMBL612546
IC50 5.95 5.95 1122.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Molecular identity unknown IC50 = 1122.02 nM 5.95 Vasorelaxing effect in Wistar rat thoracic aorta ring assessed as reduction of K... -

Data from ChEMBL 36 via Core Engine