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Assay Detail

CHEMBL3107618

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ADMET
Cytotoxicity against human A2780 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type A2780
Confidence 1 — Organism
Curated By Autocuration

Target

A2780 (CHEMBL614004)
Type CELL-LINE
Organism Homo sapiens

Publication

Isolation of antiplasmodial anthraquinones from Kniphofia ensifolia, and synthesis and structure-activity relationships of related compounds.
Dai Y, Harinantenaina L, Bowman JD, Da Fonseca IO, Brodie PJ, Goetz M, Cassera MB, Kingston DG.
Bioorg Med Chem (2014) 22 : 269 -276
PubMed 24326280 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.08 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3104733 1 5.40
CHEMBL3104732 1 5.22
CHEMBL514883 KNIPHOLONE 1 5.10
CHEMBL40275 ALOE-EMODIN 1 4.58
CHEMBL269671 ARTEMISININ 3.0 1 -
CHEMBL3104735 1 -
CHEMBL3104734 1 -
CHEMBL3104874 1 -
CHEMBL3104873 1 -
CHEMBL41092 CHRYSOPHANOL 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3104733 IC50 = 4000.0 nM 5.40
CHEMBL3104732 IC50 = 6000.0 nM 5.22
CHEMBL514883 KNIPHOLONE IC50 = 8000.0 nM 5.10
CHEMBL40275 ALOE-EMODIN IC50 = 26000.0 nM 4.58
CHEMBL269671 ARTEMISININ IC50 - -
CHEMBL3104735 IC50 > 60000.0 nM -
CHEMBL3104734 IC50 > 60000.0 nM -
CHEMBL3104874 IC50 > 60000.0 nM -
CHEMBL3104873 IC50 > 60000.0 nM -
CHEMBL41092 CHRYSOPHANOL IC50 > 60000.0 nM -