Assay Detail
ADMET
CHEMBL3107752
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Inhibition of CYP3A4 in human liver microsomes assessed as 6beta-hydroxylation of testosterone
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Two analogues of fenarimol show curative activity in an experimental model of Chagas disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.99 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3104490 | — | — | 1 | 5.40 |
| CHEMBL3104537 | — | — | 1 | 5.28 |
| CHEMBL3104479 | — | — | 1 | 5.20 |
| CHEMBL3104488 | — | — | 1 | 5.16 |
| CHEMBL3104478 | — | — | 1 | 4.92 |
| CHEMBL3104526 | — | — | 1 | 4.82 |
| CHEMBL3104376 | — | — | 1 | 4.80 |
| CHEMBL3104473 | — | — | 1 | 4.80 |
| CHEMBL3104525 | — | — | 1 | 4.77 |
| CHEMBL3104534 | — | — | 1 | 4.75 |
| CHEMBL3104375 | — | — | 1 | - |
| CHEMBL3104374 | — | — | 1 | - |
| CHEMBL3104472 | — | — | 1 | - |
| CHEMBL3104476 | — | — | 1 | - |
| CHEMBL3104485 | — | — | 1 | - |
| CHEMBL3104486 | — | — | 1 | - |
| CHEMBL3104487 | — | — | 1 | - |
| CHEMBL3104489 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3104490 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3104537 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3104479 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3104488 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3104478 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3104526 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3104376 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3104473 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3104525 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3104534 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3104375 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3104374 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3104472 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3104476 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3104485 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3104486 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3104487 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3104489 | — | IC50 | > | 20000.0 | nM | - |