Assay Detail
ADMET
CHEMBL3108257
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Cytotoxicity against rat L6 cells assessed as cell viability after 70 hrs by Alamar blue assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.28 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.77 |
| CHEMBL3216167 | — | — | 1 | 5.85 |
| CHEMBL3216615 | — | — | 1 | 5.75 |
| CHEMBL3105253 | — | — | 1 | 5.68 |
| CHEMBL3217053 | — | — | 1 | 5.68 |
| CHEMBL3217270 | — | — | 1 | 5.61 |
| CHEMBL3216850 | — | — | 1 | 5.60 |
| CHEMBL3217049 | — | — | 1 | 5.37 |
| CHEMBL3216848 | — | — | 1 | 5.36 |
| CHEMBL3217052 | — | — | 1 | 5.31 |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 5.29 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 5.19 |
| CHEMBL3217055 | — | — | 1 | 4.45 |
| CHEMBL3217056 | — | — | 1 | 4.33 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 4.33 |
| CHEMBL3215961 | — | — | 1 | 4.15 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.12 |
| CHEMBL3216170 | — | — | 1 | - |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | - |
| CHEMBL3215722 | — | — | 1 | - |
| CHEMBL3215723 | — | — | 1 | - |
| CHEMBL3216376 | — | — | 1 | - |
| CHEMBL3216614 | — | — | 1 | - |
| CHEMBL3217057 | — | — | 1 | - |
| CHEMBL3217269 | — | — | 1 | - |
| CHEMBL3217274 | — | — | 1 | - |
| CHEMBL3105271 | — | — | 1 | - |
| CHEMBL3217058 | — | — | 1 | - |
| CHEMBL3215956 | — | — | 1 | - |
| CHEMBL3215955 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3216167 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3216615 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL3105253 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL3217053 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL3217270 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL3216850 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL3217049 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL3216848 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL3217052 | — | IC50 | = | 4910.0 | nM | 5.31 |
| CHEMBL166 | MELARSOPROL | IC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3217055 | — | IC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL3217056 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 46600.0 | nM | 4.33 |
| CHEMBL3215961 | — | IC50 | = | 71200.0 | nM | 4.15 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 76500.0 | nM | 4.12 |
| CHEMBL3216170 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL269671 | ARTEMISININ | IC50 | > | 180000.0 | nM | - |
| CHEMBL3215722 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL3215723 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL3216376 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL3216614 | — | IC50 | = | 149000.0 | nM | - |
| CHEMBL3217057 | — | IC50 | = | 121000.0 | nM | - |
| CHEMBL3217269 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL3217274 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL3105271 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL3217058 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL3215956 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL3215955 | — | IC50 | > | 180000.0 | nM | - |