Assay Detail
Binding
CHEMBL3108271
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Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells after 24 hrs by firefly/renilla dual luciferase reporter gene assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 5.55 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3104353 | — | — | 1 | 6.52 |
| CHEMBL452101 | — | — | 1 | 6.40 |
| CHEMBL2235358 | — | — | 1 | 6.30 |
| CHEMBL482409 | — | — | 1 | 6.10 |
| CHEMBL517667 | — | — | 1 | 6.05 |
| CHEMBL495184 | — | — | 1 | 5.75 |
| CHEMBL274993 | 2,6-DIBENZYLIDENECYCLOHEXANONE | — | 1 | 5.70 |
| CHEMBL17205 | CYCLOVALONE | 2.0 | 1 | 5.58 |
| CHEMBL151734 | — | — | 1 | 5.51 |
| CHEMBL129134 | — | — | 1 | 5.50 |
| CHEMBL3105498 | — | — | 1 | 5.41 |
| CHEMBL270361 | — | — | 1 | 5.23 |
| CHEMBL128748 | DIMETHYLCURCUMIN | 2.0 | 1 | 5.08 |
| CHEMBL7976 | CHALCONE | — | 1 | 4.96 |
| CHEMBL472887 | — | — | 1 | 4.80 |
| CHEMBL485636 | — | — | 1 | 4.77 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3104353 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL452101 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2235358 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL482409 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL517667 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL495184 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL274993 | 2,6-DIBENZYLIDENECYCLOHEXANONE | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL17205 | CYCLOVALONE | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL151734 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL129134 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3105498 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL270361 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL128748 | DIMETHYLCURCUMIN | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL7976 | CHALCONE | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL472887 | — | EC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL485636 | — | EC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL140 | CURCUMIN | EC50 | = | 20700.0 | nM | 4.68 |