Assay Detail
Binding
CHEMBL3111112
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of biotinylated H3Kac14 peptide from His6-tagged human BAZ2B expressed in Escherichia coli BL21(DE3) after 30 mins by AlphaScreen assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bromodomain adjacent to zinc finger domain protein 2B (CHEMBL1741220) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 3.64 | 4.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3110247 | — | — | 1 | 4.43 |
| CHEMBL3110243 | — | — | 1 | 4.42 |
| CHEMBL3110244 | — | — | 1 | 3.96 |
| CHEMBL2441350 | — | — | 1 | 3.72 |
| CHEMBL3110245 | — | — | 1 | 3.62 |
| CHEMBL1650611 | — | — | 1 | 3.55 |
| CHEMBL1568712 | — | — | 1 | 3.32 |
| CHEMBL3110248 | — | — | 1 | 3.31 |
| CHEMBL528463 | — | — | 1 | 3.08 |
| CHEMBL3110246 | — | — | 1 | 2.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3110247 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3110243 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL3110244 | — | IC50 | = | 109000.0 | nM | 3.96 |
| CHEMBL2441350 | — | IC50 | = | 190000.0 | nM | 3.72 |
| CHEMBL3110245 | — | IC50 | = | 241000.0 | nM | 3.62 |
| CHEMBL1650611 | — | IC50 | = | 279000.0 | nM | 3.55 |
| CHEMBL1568712 | — | IC50 | = | 476000.0 | nM | 3.32 |
| CHEMBL3110248 | — | IC50 | = | 495000.0 | nM | 3.31 |
| CHEMBL528463 | — | IC50 | = | 826000.0 | nM | 3.08 |
| CHEMBL3110246 | — | IC50 | = | 1094000.0 | nM | 2.96 |