Assay Detail
Binding
CHEMBL3119781
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli after 30 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.75 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3115284 | — | — | 1 | 9.10 |
| CHEMBL3115283 | — | — | 1 | 9.10 |
| CHEMBL3115282 | — | — | 1 | 9.10 |
| CHEMBL3115281 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3115284 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3115283 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3115282 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3115281 | — | IC50 | = | 20.0 | nM | 7.70 |