Compound Detail
CHEMBL3115281
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Basic Information
| ChEMBL ID | CHEMBL3115281 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SDQUBUCRAGZTDH-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
404.8
MW (Da)
2.36
ALogP
5
HBA
3
HBD
108.6
PSA (Ų)
0.60
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prolyl hydroxylase EGLN3 CHEMBL5705 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prolyl hydroxylase EGLN3 | IC50 | = | 20.0 | nM | 7.7 | Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydr... | 23977883 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23977883 | 10.1021/jm400386j | Prolyl hydroxylase EGLN3 | 1 |
Data from ChEMBL 36 via Core Engine