Assay Detail
Binding
CHEMBL3128346
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human SERT T497A mutant expressed in African green monkey COS7 cells assessed as inhibition of [3H]-serotonin uptake after 3 mins by beta-scintillation counting analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.85 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3126730 | — | — | 1 | 6.77 |
| CHEMBL1516187 | — | — | 1 | 6.20 |
| CHEMBL3126751 | — | — | 1 | 4.57 |
| CHEMBL1373 | MODAFINIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3126730 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL1516187 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL3126751 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL1373 | MODAFINIL | Ki | = | 570000.0 | nM | - |