Assay Detail
Binding
CHEMBL3129498
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after 25 mins by Ellman's method
21
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.99 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3127977 | — | — | 2 | 6.54 |
| CHEMBL3127968 | — | — | 2 | 6.34 |
| CHEMBL1929421 | — | — | 1 | 6.34 |
| CHEMBL3127966 | — | — | 1 | 6.10 |
| CHEMBL3127967 | — | — | 2 | 6.08 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 6.08 |
| CHEMBL3127978 | — | — | 2 | 6.07 |
| CHEMBL3124971 | — | — | 2 | 4.64 |
| CHEMBL3127976 | — | — | 1 | - |
| CHEMBL3127975 | — | — | 1 | - |
| CHEMBL3127974 | — | — | 1 | - |
| CHEMBL3127973 | — | — | 1 | - |
| CHEMBL3127972 | — | — | 1 | - |
| CHEMBL3127971 | — | — | 1 | - |
| CHEMBL3127970 | — | — | 1 | - |
| CHEMBL3127969 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3127977 | — | IC50 | = | 289.73 | nM | 6.54 |
| CHEMBL3127977 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3127968 | — | IC50 | = | 460.26 | nM | 6.34 |
| CHEMBL1929421 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3127968 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3127966 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3127967 | — | IC50 | = | 829.85 | nM | 6.08 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL3127967 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL3127978 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3127978 | — | IC50 | = | 849.18 | nM | 6.07 |
| CHEMBL3124971 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL3124971 | — | IC50 | = | 22908.68 | nM | 4.64 |
| CHEMBL3127971 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127970 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127969 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127972 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127976 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127973 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127974 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3127975 | — | IC50 | > | 100000.0 | nM | - |