Assay Detail
ADMET
CHEMBL3129761
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Reversible inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate by LC-MS/MS analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.31 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3127501 | — | — | 1 | 5.50 |
| CHEMBL3127520 | — | — | 1 | 5.12 |
| CHEMBL3127494 | — | — | 1 | - |
| CHEMBL3127510 | — | — | 1 | - |
| CHEMBL3127509 | — | — | 1 | - |
| CHEMBL3127507 | — | — | 1 | - |
| CHEMBL3127506 | — | — | 1 | - |
| CHEMBL3127500 | — | — | 1 | - |
| CHEMBL3127526 | — | — | 1 | - |
| CHEMBL3127525 | — | — | 1 | - |
| CHEMBL3127522 | — | — | 1 | - |
| CHEMBL3127521 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3127501 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3127520 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3127494 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3127510 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3127509 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3127507 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3127506 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3127500 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3127526 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3127525 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3127522 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3127521 | — | IC50 | > | 10000.0 | nM | - |