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Assay Detail

CHEMBL3129818

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]IMPY from amyloid beta (1 to 40) (unknown origin) after 2 hrs by gamma counting analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amyloid-beta precursor protein (CHEMBL2487)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Homoisoflavonoids as potential imaging agents for β-amyloid plaques in Alzheimer's disease.
Gan C, Zhao Z, Nan DD, Yin B, Hu J.
Eur J Med Chem (2014) 76 : 125 -131
PubMed 24583352 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 7.28 8.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3126514 1 8.04
CHEMBL3126511 1 8.00
CHEMBL71696 1 7.87
CHEMBL3126518 1 7.59
CHEMBL3126522 1 7.41
CHEMBL3126519 1 7.27
CHEMBL3126516 1 7.20
CHEMBL3126520 1 7.13
CHEMBL3126513 1 6.99
CHEMBL3126512 1 6.99
CHEMBL3126515 1 6.97
CHEMBL3126517 1 6.84
CHEMBL3126521 1 6.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3126514 Ki = 9.1 nM 8.04
CHEMBL3126511 Ki = 9.98 nM 8.00
CHEMBL71696 Ki = 13.65 nM 7.87
CHEMBL3126518 Ki = 25.54 nM 7.59
CHEMBL3126522 Ki = 39.19 nM 7.41
CHEMBL3126519 Ki = 54.22 nM 7.27
CHEMBL3126516 Ki = 63.57 nM 7.20
CHEMBL3126520 Ki = 73.46 nM 7.13
CHEMBL3126513 Ki = 103.62 nM 6.99
CHEMBL3126512 Ki = 103.35 nM 6.99
CHEMBL3126515 Ki = 107.6 nM 6.97
CHEMBL3126517 Ki = 143.81 nM 6.84
CHEMBL3126521 Ki = 432.03 nM 6.36