Assay Detail
Functional
CHEMBL3131241
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Inhibition of human SOD1 expressed in mouse fibroblasts after 48 hrs by ELISA relative to control
10
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Fibroblast |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 1,3,4-oxidiazole scaffold compounds as inhibitors of superoxide dismutase expression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.58 | 6.20 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288064 | — | — | 2 | 6.20 |
| CHEMBL142711 | — | — | 1 | 6.19 |
| CHEMBL102714 | SB-216763 | — | 1 | 5.52 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 5.00 |
| CHEMBL272629 | — | — | 1 | 5.00 |
| CHEMBL75680 | ALOISINE A | — | 1 | - |
| CHEMBL3125371 | — | — | 1 | - |
| CHEMBL3125374 | — | — | 1 | - |
| CHEMBL3125370 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288064 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL142711 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL102714 | SB-216763 | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL272629 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL75680 | ALOISINE A | IC50 | - | — | - | |
| CHEMBL288064 | — | Inhibition | - | % | - | |
| CHEMBL3125371 | — | Inhibition | - | % | - | |
| CHEMBL3125374 | — | Inhibition | - | % | - | |
| CHEMBL3125370 | — | IC50 | - | — | - |