Assay Detail
Binding
CHEMBL3136676
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to L3MBTL3 (unknown origin) by isothermal titration calorimetric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lethal(3)malignant brain tumor-like protein 3 (CHEMBL1287623) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 5.62 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3134131 | — | — | 1 | 6.43 |
| CHEMBL3134146 | — | — | 1 | 6.40 |
| CHEMBL3134126 | — | — | 1 | 6.21 |
| CHEMBL3134133 | — | — | 1 | 5.85 |
| CHEMBL3134134 | — | — | 1 | 5.75 |
| CHEMBL3134132 | — | — | 1 | 5.62 |
| CHEMBL3134135 | — | — | 1 | 5.57 |
| CHEMBL3134138 | — | — | 1 | 4.42 |
| CHEMBL3134141 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3134131 | — | Kd | = | 370.0 | nM | 6.43 |
| CHEMBL3134146 | — | Kd | = | 400.0 | nM | 6.40 |
| CHEMBL3134126 | — | Kd | = | 610.0 | nM | 6.21 |
| CHEMBL3134133 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL3134134 | — | Kd | = | 1800.0 | nM | 5.75 |
| CHEMBL3134132 | — | Kd | = | 2400.0 | nM | 5.62 |
| CHEMBL3134135 | — | Kd | = | 2700.0 | nM | 5.57 |
| CHEMBL3134138 | — | Kd | = | 38000.0 | nM | 4.42 |
| CHEMBL3134141 | — | Kd | = | 44000.0 | nM | 4.36 |