Compound Detail
CHEMBL3134138
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Basic Information
| ChEMBL ID | CHEMBL3134138 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WFWJFGLKDLIHNR-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
355.5
MW (Da)
3.31
ALogP
3
HBA
0
HBD
26.8
PSA (Ų)
0.81
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.62
Kd 1 meas. best 4.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lethal(3)malignant brain tumor-like protein 3 CHEMBL1287623 | IC50 | 5.62 | 5.62 | 2400.0 | 1 |
| Lethal(3)malignant brain tumor-like protein 3 CHEMBL1287623 | Kd | 4.42 | 4.42 | 38000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lethal(3)malignant brain tumor-like protein 3 | IC50 | = | 2400.0 | nM | 5.62 | Inhibition of His-tagged L3MBTL3 (unknown origin) using H4K20Me2 as substrate in... | 24466405 |
| Lethal(3)malignant brain tumor-like protein 3 | Kd | = | 38000.0 | nM | 4.42 | Binding affinity to L3MBTL3 (unknown origin) by isothermal titration calorimetri... | 24466405 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24466405 | 10.1039/c3md00197k | Lethal(3)malignant brain tumor-like protein 3 | 2 |
| 24466405 | 10.1039/c3md00197k | PHD finger protein 23 | 1 |
| 24466405 | 10.1039/c3md00197k | Lysine-specific demethylase 5A | 1 |
| 24466405 | 10.1039/c3md00197k | E3 ubiquitin-protein ligase UHRF1 | 1 |
| 24466405 | 10.1039/c3md00197k | Chromobox protein homolog 7 | 1 |
| 24466405 | 10.1039/c3md00197k | TP53-binding protein 1 | 1 |
| 24466405 | 10.1039/c3md00197k | MBT domain-containing protein 1 | 1 |
| 24466405 | 10.1039/c3md00197k | Lethal(3)malignant brain tumor-like protein 1 | 1 |
Data from ChEMBL 36 via Core Engine