Assay Detail
Binding
CHEMBL3226383
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Inhibition of ROCK1 (unknown origin)
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.37 | 9.28 |
| Ki | 1 | 6.66 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3218297 | — | — | 1 | 9.28 |
| CHEMBL559147 | Y-27632 | — | 1 | 6.66 |
| CHEMBL38380 | FASUDIL | 3.0 | 1 | 6.58 |
| CHEMBL2419278 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3218297 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL559147 | Y-27632 | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL38380 | FASUDIL | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2419278 | — | IC50 | = | 570.0 | nM | 6.24 |