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Assay Detail

CHEMBL3227739

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human FAAH expressed in HEK293 cells using arachadonyl 7-amino 4-methyl coumarin amide as substrate by fluorimetric assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fatty-acid amide hydrolase 1 (CHEMBL2243)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2-Amino-5-arylbenzoxazole derivatives as potent inhibitors of fatty acid amide hydrolase (FAAH)
Estiarte MA, Johnson RJ, Kaub CJ, Gowlugari S, O'Mahony DJR, Nguyen MT, Emerling DE, Kelly MG, Kincaid J, Vincent F, Duncton MAJ
Medchemcomm (2012) 3 : 611 -619
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 7.27 8.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3217945 1 8.92
CHEMBL1812716 1 8.89
CHEMBL184238 URB-597 1.0 1 8.64
CHEMBL3217946 1 8.49
CHEMBL560590 1 8.34
CHEMBL3217941 1 8.00
CHEMBL3217943 1 8.00
CHEMBL3222191 1 7.92
CHEMBL3217942 1 7.89
CHEMBL3217944 1 7.85
CHEMBL3217947 1 7.75
CHEMBL3217940 1 7.55
CHEMBL3217939 1 7.38
CHEMBL3222177 1 7.32
CHEMBL3222176 1 7.28
CHEMBL3222168 1 7.27
CHEMBL3222190 1 7.26
CHEMBL3222175 1 7.21
CHEMBL3222189 1 7.20
CHEMBL3222179 1 7.17
CHEMBL3222180 1 7.00
CHEMBL3217938 1 6.92
CHEMBL3222187 1 6.78
CHEMBL3222182 1 6.73
CHEMBL3222172 1 6.68
CHEMBL3217937 1 6.68
CHEMBL3222174 1 6.67
CHEMBL3217801 1 6.65
CHEMBL3222167 1 6.64
CHEMBL3222181 1 6.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3217945 IC50 = 1.2 nM 8.92
CHEMBL1812716 IC50 = 1.3 nM 8.89
CHEMBL184238 URB-597 IC50 = 2.3 nM 8.64
CHEMBL3217946 IC50 = 3.2 nM 8.49
CHEMBL560590 IC50 = 4.6 nM 8.34
CHEMBL3217941 IC50 = 10.0 nM 8.00
CHEMBL3217943 IC50 = 10.0 nM 8.00
CHEMBL3222191 IC50 = 12.0 nM 7.92
CHEMBL3217942 IC50 = 13.0 nM 7.89
CHEMBL3217944 IC50 = 14.0 nM 7.85
CHEMBL3217947 IC50 = 18.0 nM 7.75
CHEMBL3217940 IC50 = 28.0 nM 7.55
CHEMBL3217939 IC50 = 42.0 nM 7.38
CHEMBL3222177 IC50 = 48.0 nM 7.32
CHEMBL3222176 IC50 = 52.0 nM 7.28
CHEMBL3222168 IC50 = 54.0 nM 7.27
CHEMBL3222190 IC50 = 55.0 nM 7.26
CHEMBL3222175 IC50 = 61.0 nM 7.21
CHEMBL3222189 IC50 = 63.0 nM 7.20
CHEMBL3222179 IC50 = 68.0 nM 7.17
CHEMBL3222180 IC50 = 99.0 nM 7.00
CHEMBL3217938 IC50 = 121.0 nM 6.92
CHEMBL3222187 IC50 = 168.0 nM 6.78
CHEMBL3222182 IC50 = 186.0 nM 6.73
CHEMBL3222172 IC50 = 207.0 nM 6.68
CHEMBL3217937 IC50 = 211.0 nM 6.68
CHEMBL3222174 IC50 = 214.0 nM 6.67
CHEMBL3217801 IC50 = 226.0 nM 6.65
CHEMBL3222167 IC50 = 228.0 nM 6.64
CHEMBL3222181 IC50 = 280.0 nM 6.55
CHEMBL3222178 IC50 = 488.0 nM 6.31
CHEMBL3222173 IC50 = 579.0 nM 6.24
CHEMBL3222185 IC50 = 674.0 nM 6.17
CHEMBL3222186 IC50 = 784.0 nM 6.11
CHEMBL3222169 IC50 = 911.0 nM 6.04
CHEMBL3222165 IC50 > 1000.0 nM -
CHEMBL3222166 IC50 > 1000.0 nM -
CHEMBL3222170 IC50 > 1000.0 nM -
CHEMBL3222171 IC50 > 1000.0 nM -
CHEMBL3222183 IC50 > 1000.0 nM -
CHEMBL3222184 IC50 > 1000.0 nM -
CHEMBL3222188 IC50 > 1000.0 nM -
CHEMBL3217948 IC50 > 1000.0 nM -
CHEMBL3217949 IC50 > 1000.0 nM -