Assay Detail
Binding
CHEMBL3227799
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-naloxone from human mu opioid receptor expressed in CHO cells after 1 hr
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Bivalent Ligand Targeting the Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Heterodimers: Binding Affinity versus Functional Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.16 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 9.15 |
| CHEMBL3219778 | — | — | 1 | 8.04 |
| CHEMBL3219777 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19019 | NALTREXONE | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL3219778 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL3219777 | — | Ki | = | 51.8 | nM | 7.29 |