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Assay Detail

CHEMBL3238652

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to sigma-1 opioid receptor (unknown origin)
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sigma non-opioid intracellular receptor 1 (CHEMBL287)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The σ2 receptor: a novel protein for the imaging and treatment of cancer.
Mach RH, Zeng C, Hawkins WG.
J Med Chem (2013) 56 : 7137 -7160
PubMed 23734634 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 6.09 8.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL64683 1 8.89
CHEMBL3235106 1 8.00
CHEMBL3235467 1 7.98
CHEMBL61479 SIRAMESINE 2.0 1 7.77
CHEMBL2111685 1 7.56
CHEMBL59713 1 6.09
CHEMBL62994 1 5.92
CHEMBL481418 1 5.84
CHEMBL3235107 1 5.83
CHEMBL64176 1 5.53
CHEMBL3235466 1 5.51
CHEMBL60048 1 5.51
CHEMBL64261 1 5.26
CHEMBL3235468 1 5.13
CHEMBL222287 IBOGAINE 2.0 1 5.07
CHEMBL2030624 1 5.00
CHEMBL1927694 1 4.99
CHEMBL64260 1 4.98
CHEMBL291439 1 4.89
CHEMBL45951 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL64683 Ki = 1.3 nM 8.89
CHEMBL3235106 Ki = 10.0 nM 8.00
CHEMBL3235467 Ki = 10.5 nM 7.98
CHEMBL61479 SIRAMESINE Ki = 17.0 nM 7.77
CHEMBL2111685 Ki = 27.3 nM 7.56
CHEMBL59713 Ki = 809.0 nM 6.09
CHEMBL62994 Ki = 1200.0 nM 5.92
CHEMBL481418 Ki = 1437.0 nM 5.84
CHEMBL3235107 Ki = 1492.0 nM 5.83
CHEMBL64176 Ki = 2932.0 nM 5.53
CHEMBL3235466 Ki = 3063.0 nM 5.51
CHEMBL60048 Ki = 3078.0 nM 5.51
CHEMBL64261 Ki = 5484.0 nM 5.26
CHEMBL3235468 Ki = 7436.0 nM 5.13
CHEMBL222287 IBOGAINE Ki = 8554.0 nM 5.07
CHEMBL2030624 Ki = 10000.0 nM 5.00
CHEMBL1927694 Ki = 10320.0 nM 4.99
CHEMBL64260 Ki = 10400.0 nM 4.98
CHEMBL291439 Ki = 12900.0 nM 4.89
CHEMBL45951 Ki > 1000.0 nM -