Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3239823

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human CB2 receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cannabinoid receptor 2 (CHEMBL253)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.
Han S, Thatte J, Buzard DJ, Jones RM.
J Med Chem (2013) 56 : 8224 -8256
PubMed 23865723 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 7.86 10.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3233404 1 10.49
CHEMBL307696 1 9.66
CHEMBL411626 1 9.31
CHEMBL559612 CP-55940 1 9.16
CHEMBL2218896 NABILONE 4.0 1 8.73
CHEMBL371214 1 8.47
CHEMBL3234035 PRS-211375 2.0 1 8.05
CHEMBL294013 1 7.71
CHEMBL57367 1 7.70
CHEMBL3233405 1 7.50
CHEMBL465 DRONABINOL 4.0 1 7.44
CHEMBL456341 LENABASUM 3.0 1 6.77
CHEMBL122972 2-ARACHIDONOYLGLYCEROL 1 5.85
CHEMBL190461 CANNABIDIOL 4.0 1 5.54
CHEMBL146346 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3233404 Ki = 0.032 nM 10.49
CHEMBL307696 Ki = 0.22 nM 9.66
CHEMBL411626 Ki = 0.49 nM 9.31
CHEMBL559612 CP-55940 Ki = 0.69 nM 9.16
CHEMBL2218896 NABILONE Ki = 1.84 nM 8.73
CHEMBL371214 Ki = 3.4 nM 8.47
CHEMBL3234035 PRS-211375 Ki = 9.0 nM 8.05
CHEMBL294013 Ki = 19.4 nM 7.71
CHEMBL57367 Ki = 20.0 nM 7.70
CHEMBL3233405 Ki = 32.0 nM 7.50
CHEMBL465 DRONABINOL Ki = 36.4 nM 7.44
CHEMBL456341 LENABASUM Ki = 170.5 nM 6.77
CHEMBL122972 2-ARACHIDONOYLGLYCEROL Ki = 1400.0 nM 5.85
CHEMBL190461 CANNABIDIOL Ki = 2860.0 nM 5.54
CHEMBL146346 Ki = 3000.0 nM 5.52