Assay Detail
Binding
CHEMBL3240143
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Inhibition of truncated ROCK-1 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vivo optimization of 2,3-diaminopyrazine Rho Kinase inhibitors for the treatment of glaucoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.64 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3238167 | — | — | 1 | 6.98 |
| CHEMBL571948 | Y-39983 | 1.0 | 1 | 6.92 |
| CHEMBL3238168 | — | — | 1 | 6.85 |
| CHEMBL3238166 | — | — | 1 | 6.69 |
| CHEMBL3238163 | — | — | 1 | 6.54 |
| CHEMBL3238164 | — | — | 1 | 6.46 |
| CHEMBL3238165 | — | — | 1 | 6.46 |
| CHEMBL599163 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3238167 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL571948 | Y-39983 | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3238168 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3238166 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL3238163 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL3238164 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3238165 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL599163 | — | IC50 | = | 570.0 | nM | 6.24 |