Assay Detail
Functional
CHEMBL3240408
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HT-22 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Functionalized acridin-9-yl phenylamines protected neuronal HT22 cells from glutamate-induced cell death by reducing intracellular levels of free radical species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 39 | 6.16 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1333512 | N,N'-DIPHENYL-P-PHENYLENEDIAMINE | — | 1 | 8.11 |
| CHEMBL572203 | — | — | 1 | 7.58 |
| CHEMBL3237346 | — | — | 1 | 6.75 |
| CHEMBL471927 | — | — | 1 | 6.57 |
| CHEMBL471732 | — | — | 1 | 6.52 |
| CHEMBL511319 | — | — | 1 | 6.51 |
| CHEMBL472129 | — | — | 1 | 6.48 |
| CHEMBL460881 | — | — | 1 | 6.46 |
| CHEMBL2153414 | — | — | 1 | 6.41 |
| CHEMBL2153290 | — | — | 1 | 6.41 |
| CHEMBL461295 | — | — | 1 | 6.39 |
| CHEMBL516969 | — | — | 1 | 6.37 |
| CHEMBL460679 | — | — | 1 | 6.36 |
| CHEMBL517113 | — | — | 1 | 6.35 |
| CHEMBL471733 | — | — | 1 | 6.30 |
| CHEMBL2153289 | — | — | 1 | 6.30 |
| CHEMBL2153293 | — | — | 1 | 6.27 |
| CHEMBL512898 | — | — | 1 | 6.21 |
| CHEMBL471922 | — | — | 1 | 6.20 |
| CHEMBL586902 | — | — | 1 | 6.20 |
| CHEMBL2153288 | — | — | 1 | 6.19 |
| CHEMBL315530 | — | — | 1 | 6.13 |
| CHEMBL3237344 | — | — | 1 | 6.11 |
| CHEMBL3237348 | — | — | 1 | 6.07 |
| CHEMBL403741 | — | — | 1 | 6.06 |
| CHEMBL3237349 | — | — | 1 | 6.05 |
| CHEMBL3237355 | — | — | 1 | 5.99 |
| CHEMBL2153291 | — | — | 1 | 5.94 |
| CHEMBL3237345 | — | — | 1 | 5.87 |
| CHEMBL1811978 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1333512 | N,N'-DIPHENYL-P-PHENYLENEDIAMINE | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL572203 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3237346 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL471927 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL471732 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL511319 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL472129 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL460881 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2153414 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL2153290 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL461295 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL516969 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL460679 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL517113 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL2153289 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL471733 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2153293 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL512898 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL586902 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL471922 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL2153288 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL315530 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL3237344 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL3237348 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL403741 | — | EC50 | = | 879.0 | nM | 6.06 |
| CHEMBL3237349 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3237355 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL2153291 | — | EC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL3237345 | — | EC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL1811978 | — | EC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL292314 | — | EC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL3237357 | — | EC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL3237356 | — | EC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL3237350 | — | EC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL1424003 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3237347 | — | EC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL50 | QUERCETIN | EC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL2153295 | — | EC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL538 | ANILINE | EC50 | = | 9400.0 | nM | 5.03 |