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Assay Detail

CHEMBL3240699

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Binding
Inhibition of rabbit muscle glycogen phosphorylase b
27
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glycogen phosphorylase, muscle form (CHEMBL4696)
Type SINGLE PROTEIN
Organism Oryctolagus cuniculus

Publication

New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase.
Kun S, Bokor É, Varga G, Szőcs B, Páhi A, Czifrák K, Tóth M, Juhász L, Docsa T, Gergely P, Somsák L.
Eur J Med Chem (2014) 76 : 567 -579
PubMed 24608000 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 26 5.03 6.39
Inhibition 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2408225 1 6.39
CHEMBL3237972 1 6.17
CHEMBL3237966 1 5.77
CHEMBL3237970 1 5.72
CHEMBL3237963 1 5.68
CHEMBL3237969 1 5.54
CHEMBL2408224 1 5.16
CHEMBL558445 1 5.05
CHEMBL488967 1 5.00
CHEMBL549843 1 4.92
CHEMBL3237976 1 4.85
CHEMBL600003 1 4.80
CHEMBL549701 1 4.57
CHEMBL3351143 1 4.50
CHEMBL3237971 1 4.47
CHEMBL560324 1 4.42
CHEMBL3237974 1 4.40
CHEMBL559793 1 4.12
CHEMBL3351140 1 4.09
CHEMBL3237964 1 -
CHEMBL3237977 1 -
CHEMBL3237968 1 -
CHEMBL3237967 1 -
CHEMBL2408223 1 -
CHEMBL601227 1 -
CHEMBL540929 1 -
CHEMBL561789 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2408225 Ki = 410.0 nM 6.39
CHEMBL3237972 Ki = 670.0 nM 6.17
CHEMBL3237966 Ki = 1700.0 nM 5.77
CHEMBL3237970 Ki = 1900.0 nM 5.72
CHEMBL3237963 Ki = 2100.0 nM 5.68
CHEMBL3237969 Ki = 2900.0 nM 5.54
CHEMBL2408224 Ki = 7000.0 nM 5.16
CHEMBL558445 Ki = 9000.0 nM 5.05
CHEMBL488967 Ki = 10000.0 nM 5.00
CHEMBL549843 Ki = 12000.0 nM 4.92
CHEMBL3237976 Ki = 14000.0 nM 4.85
CHEMBL600003 Ki = 16000.0 nM 4.80
CHEMBL549701 Ki = 27000.0 nM 4.57
CHEMBL3351143 Ki = 32000.0 nM 4.50
CHEMBL3237971 Ki = 33500.0 nM 4.47
CHEMBL560324 Ki = 38000.0 nM 4.42
CHEMBL3237974 Ki = 39700.0 nM 4.40
CHEMBL559793 Ki = 76000.0 nM 4.12
CHEMBL3351140 Ki = 81000.0 nM 4.09
CHEMBL3237964 Ki = 499000.0 nM -
CHEMBL3237977 Ki = 707000.0 nM -
CHEMBL3237968 Ki = 111000.0 nM -
CHEMBL3237967 Ki = 778000.0 nM -
CHEMBL2408223 Ki = 105000.0 nM -
CHEMBL601227 Ki = 151000.0 nM -
CHEMBL540929 Ki = 145000.0 nM -
CHEMBL561789 Inhibition - % -