Assay Detail
Binding
CHEMBL3241202
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]Tyr0sauvagine from human CRF1 receptor expressed in HEK293 cell membrane after 120 mins by gamma scintillation counting analysis
9
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of substituted pyrimidines as corticotropin releasing factor (CRF) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.68 | 7.73 |
| Inhibition | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296641 | ANTALARMIN | — | 1 | 7.73 |
| CHEMBL3235706 | — | — | 2 | 6.61 |
| CHEMBL3235700 | — | — | 2 | 6.56 |
| CHEMBL3235703 | — | — | 2 | 6.27 |
| CHEMBL3235705 | — | — | 2 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296641 | ANTALARMIN | IC50 | = | 18.62 | nM | 7.73 |
| CHEMBL3235706 | — | IC50 | = | 245.47 | nM | 6.61 |
| CHEMBL3235700 | — | IC50 | = | 275.42 | nM | 6.56 |
| CHEMBL3235703 | — | IC50 | = | 537.03 | nM | 6.27 |
| CHEMBL3235705 | — | IC50 | = | 588.84 | nM | 6.23 |
| CHEMBL3235700 | — | Inhibition | - | % | - | |
| CHEMBL3235703 | — | Inhibition | - | % | - | |
| CHEMBL3235705 | — | Inhibition | - | % | - | |
| CHEMBL3235706 | — | Inhibition | - | % | - |