Assay Detail
Binding
CHEMBL3242257
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of FITC-geldanamycin from recombinant HSP90beta (unknown origin) after 2 hrs by fluorescence polarization assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of novel HSP90α/β isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 7.31 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3235355 | — | — | 1 | 8.52 |
| CHEMBL3235353 | — | — | 1 | 8.30 |
| CHEMBL3235354 | — | — | 1 | 8.30 |
| CHEMBL3235361 | — | — | 1 | 8.00 |
| CHEMBL3235335 | — | — | 1 | 7.92 |
| CHEMBL3235360 | — | — | 1 | 7.82 |
| CHEMBL3235336 | — | — | 1 | 7.72 |
| CHEMBL3235362 | — | — | 1 | 7.70 |
| CHEMBL3235339 | — | — | 1 | 7.68 |
| CHEMBL3235342 | — | — | 1 | 7.66 |
| CHEMBL3235344 | — | — | 1 | 7.66 |
| CHEMBL3235338 | — | — | 1 | 7.60 |
| CHEMBL3235343 | — | — | 1 | 7.60 |
| CHEMBL3235352 | — | — | 1 | 7.58 |
| CHEMBL3235341 | — | — | 1 | 7.54 |
| CHEMBL3235345 | — | — | 1 | 7.52 |
| CHEMBL3235333 | — | — | 1 | 7.51 |
| CHEMBL3235334 | — | — | 1 | 7.46 |
| CHEMBL3235350 | — | — | 1 | 7.43 |
| CHEMBL3235356 | — | — | 1 | 7.41 |
| CHEMBL3235363 | — | — | 1 | 7.40 |
| CHEMBL3235351 | — | — | 1 | 7.40 |
| CHEMBL3235340 | — | — | 1 | 7.32 |
| CHEMBL3235357 | — | — | 1 | 7.25 |
| CHEMBL3235337 | — | — | 1 | 7.22 |
| CHEMBL3235359 | — | — | 1 | 6.92 |
| CHEMBL3235358 | — | — | 1 | 6.85 |
| CHEMBL3235349 | — | — | 1 | 6.38 |
| CHEMBL3235330 | — | — | 1 | 6.24 |
| CHEMBL3235347 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3235355 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3235353 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL3235354 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL3235361 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3235335 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3235360 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL3235336 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3235362 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3235339 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3235342 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3235344 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3235338 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3235343 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3235352 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL3235341 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL3235345 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL3235333 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3235334 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL3235350 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL3235356 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL3235351 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL3235363 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL3235340 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL3235357 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL3235337 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL3235359 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3235358 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL3235349 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL3235330 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL3235347 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL3235332 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL3235328 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL3235329 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL3235348 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3235346 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3235331 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3235327 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3235326 | — | Ki | > | 10000.0 | nM | - |