Assay Detail
Binding
CHEMBL3242489
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Binding affinity to immobilized recombinant mouse CD44 hyaluronan binding domain by surface plasmon resonance assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fragment-based identification of an inducible binding site on cell surface receptor CD44 for the design of protein-carbohydrate interaction inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 3.66 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237623 | — | — | 1 | 5.19 |
| CHEMBL3237622 | — | — | 1 | 4.66 |
| CHEMBL3237621 | — | — | 1 | 4.49 |
| CHEMBL3237620 | — | — | 1 | 4.23 |
| CHEMBL3237627 | — | — | 1 | 3.30 |
| CHEMBL3237624 | — | — | 1 | 2.96 |
| CHEMBL3237626 | — | — | 1 | 2.26 |
| CHEMBL3183504 | — | — | 1 | 2.19 |
| CHEMBL3237619 | — | — | 1 | - |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | — | 1 | - |
| CHEMBL3237625 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237623 | — | Kd | = | 6400.0 | nM | 5.19 |
| CHEMBL3237622 | — | Kd | = | 21700.0 | nM | 4.66 |
| CHEMBL3237621 | — | Kd | = | 32700.0 | nM | 4.49 |
| CHEMBL3237620 | — | Kd | = | 58400.0 | nM | 4.23 |
| CHEMBL3237627 | — | Kd | = | 500000.0 | nM | 3.30 |
| CHEMBL3237624 | — | Kd | = | 1100000.0 | nM | 2.96 |
| CHEMBL3237626 | — | Kd | = | 5500000.0 | nM | 2.26 |
| CHEMBL3183504 | — | Kd | = | 6400000.0 | nM | 2.19 |
| CHEMBL3237619 | — | Kd | = | 428000.0 | nM | - |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | Kd | = | 11200000.0 | nM | - |
| CHEMBL3237625 | — | Kd | = | 12600000.0 | nM | - |