Assay Detail
Functional
CHEMBL3242953
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Antiproliferative activity against human DU145 cells assessed as cell viability after 72 hrs by CCK8 assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.94 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.40 |
| CHEMBL3237181 | — | — | 1 | 6.30 |
| CHEMBL3237174 | — | — | 1 | 6.21 |
| CHEMBL3237168 | — | — | 1 | 6.20 |
| CHEMBL3237172 | — | — | 1 | 6.10 |
| CHEMBL3237176 | — | — | 1 | 6.10 |
| CHEMBL3237169 | — | — | 1 | 6.05 |
| CHEMBL3237167 | — | — | 1 | 6.03 |
| CHEMBL3237164 | — | — | 1 | 5.92 |
| CHEMBL3237166 | — | — | 1 | 5.90 |
| CHEMBL3237165 | — | — | 1 | 5.87 |
| CHEMBL3237188 | — | — | 1 | 5.65 |
| CHEMBL3237184 | — | — | 1 | 5.58 |
| CHEMBL3237187 | — | — | 1 | 5.51 |
| CHEMBL3237185 | — | — | 1 | 5.30 |
| CHEMBL3237180 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL572878 | TOZASERTIB | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3237181 | — | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL3237174 | — | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL3237168 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL3237172 | — | IC50 | = | 798.0 | nM | 6.10 |
| CHEMBL3237176 | — | IC50 | = | 791.0 | nM | 6.10 |
| CHEMBL3237169 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3237167 | — | IC50 | = | 926.0 | nM | 6.03 |
| CHEMBL3237164 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3237166 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL3237165 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL3237188 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL3237184 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL3237187 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL3237185 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL3237180 | — | IC50 | - | — | - |