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Assay Detail

CHEMBL3265463

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Analgesic activity in C57Bl/6 mouse assessed as inhibition of Bv8-induced decrease in latencies to paw withdrawal administered as intraplantar route at 48 degC after 15 to 180 mins
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Confidence 1 — Organism
Curated By Autocuration

Target

Mus musculus (CHEMBL375)
Type ORGANISM
Organism Mus musculus

Publication

A new convenient synthetic method and preliminary pharmacological characterization of triazinediones as prokineticin receptor antagonists.
Congiu C, Onnis V, Deplano A, Salvadori S, Marconi V, Maftei D, Negri L, Lattanzi R, Balboni G.
Eur J Med Chem (2014) 81 : 334 -340
PubMed 24852280 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 10.34 10.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3265375 1 10.44
CHEMBL3265379 1 10.41
CHEMBL3265378 1 10.41
CHEMBL3265381 1 10.32
CHEMBL3265377 1 10.32
CHEMBL3265380 1 10.29
CHEMBL3265368 1 10.29
CHEMBL3265366 1 10.20
CHEMBL550577 1 -
CHEMBL3265367 1 -
CHEMBL562111 1 -
CHEMBL551383 1 -
CHEMBL3265369 1 -
CHEMBL3265370 1 -
CHEMBL3265371 1 -
CHEMBL457515 1 -
CHEMBL3265373 1 -
CHEMBL3265374 1 -
CHEMBL3265376 1 -
CHEMBL3265372 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3265375 EC50 = 0.036 nM 10.44
CHEMBL3265379 EC50 = 0.039 nM 10.41
CHEMBL3265378 EC50 = 0.039 nM 10.41
CHEMBL3265381 EC50 = 0.048 nM 10.32
CHEMBL3265377 EC50 = 0.048 nM 10.32
CHEMBL3265380 EC50 = 0.051 nM 10.29
CHEMBL3265368 EC50 = 0.051 nM 10.29
CHEMBL3265366 EC50 = 0.063 nM 10.20
CHEMBL550577 EC50 = 0.00031 nM -
CHEMBL3265367 EC50 = 0.0044 nM -
CHEMBL562111 EC50 = 5.3e-05 nM -
CHEMBL551383 EC50 = 0.004 nM -
CHEMBL3265369 EC50 = 0.0043 nM -
CHEMBL3265370 EC50 = 0.00036 nM -
CHEMBL3265371 EC50 = 0.0045 nM -
CHEMBL457515 EC50 = 0.0058 nM -
CHEMBL3265373 EC50 = 0.0051 nM -
CHEMBL3265374 EC50 = 0.0045 nM -
CHEMBL3265376 EC50 = 0.0044 nM -
CHEMBL3265372 EC50 = 3.3e-05 nM -