Assay Detail
Binding
CHEMBL3266136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at glucocorticoid receptor in human PBMC assessed as inhibition of LPS-stimulated TNF-alpha release
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery of potent and selective non-steroidal glucocorticoid receptor modulators, suitable for inhalation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.99 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3261410 | — | — | 1 | 8.80 |
| CHEMBL3261412 | — | — | 1 | 8.70 |
| CHEMBL3261416 | — | — | 1 | 8.68 |
| CHEMBL3261411 | — | — | 1 | 8.09 |
| CHEMBL3261409 | — | — | 1 | 8.06 |
| CHEMBL3261415 | — | — | 1 | 7.92 |
| CHEMBL3261420 | — | — | 1 | 7.92 |
| CHEMBL3261413 | — | — | 1 | 7.89 |
| CHEMBL3261427 | — | — | 1 | 7.89 |
| CHEMBL3261407 | — | — | 1 | 7.85 |
| CHEMBL3261425 | — | — | 1 | 7.85 |
| CHEMBL3261408 | — | — | 1 | 7.64 |
| CHEMBL3261414 | — | — | 1 | 7.64 |
| CHEMBL3261417 | — | — | 1 | 7.55 |
| CHEMBL3261423 | — | — | 1 | 7.44 |
| CHEMBL3261418 | — | — | 1 | - |
| CHEMBL3261419 | — | — | 1 | - |
| CHEMBL3261421 | — | — | 1 | - |
| CHEMBL3261422 | — | — | 1 | - |
| CHEMBL3261424 | — | — | 1 | - |
| CHEMBL3261426 | — | — | 1 | - |
| CHEMBL3261429 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3261410 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3261412 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3261416 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3261411 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL3261409 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL3261415 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3261420 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3261413 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3261427 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3261407 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3261425 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3261408 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3261414 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3261417 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3261423 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3261418 | — | IC50 | - | — | - | |
| CHEMBL3261419 | — | IC50 | - | — | - | |
| CHEMBL3261421 | — | IC50 | - | — | - | |
| CHEMBL3261422 | — | IC50 | - | — | - | |
| CHEMBL3261424 | — | IC50 | - | — | - | |
| CHEMBL3261426 | — | IC50 | - | — | - | |
| CHEMBL3261429 | — | IC50 | - | — | - |