Assay Detail
Functional
CHEMBL3266491
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Cytotoxicity against mouse B16F10 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16-F10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of xanthone derivatives based on α-mangostin and their biological evaluation for anti-cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.92 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.92 |
| CHEMBL323197 | MANGOSTIN | — | 1 | 5.49 |
| CHEMBL3261720 | — | — | 1 | 5.18 |
| CHEMBL3261722 | — | — | 1 | 4.91 |
| CHEMBL3261723 | — | — | 1 | 4.91 |
| CHEMBL3261709 | — | — | 1 | 4.88 |
| CHEMBL3261719 | — | — | 1 | 4.84 |
| CHEMBL465553 | — | — | 1 | 4.82 |
| CHEMBL3261713 | — | — | 1 | 4.81 |
| CHEMBL3261712 | — | — | 1 | 4.78 |
| CHEMBL3261716 | — | — | 1 | 4.78 |
| CHEMBL561643 | MANGOSTANIN | — | 1 | 4.58 |
| CHEMBL3261710 | — | — | 1 | 4.54 |
| CHEMBL3261715 | — | — | 1 | 4.39 |
| CHEMBL3261711 | — | — | 1 | 4.02 |
| CHEMBL463293 | — | — | 1 | - |
| CHEMBL3261714 | — | — | 1 | - |
| CHEMBL3261717 | — | — | 1 | - |
| CHEMBL3261718 | — | — | 1 | - |
| CHEMBL464119 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL323197 | MANGOSTIN | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL3261720 | — | IC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL3261722 | — | IC50 | = | 12340.0 | nM | 4.91 |
| CHEMBL3261723 | — | IC50 | = | 12440.0 | nM | 4.91 |
| CHEMBL3261709 | — | IC50 | = | 13060.0 | nM | 4.88 |
| CHEMBL3261719 | — | IC50 | = | 14380.0 | nM | 4.84 |
| CHEMBL465553 | — | IC50 | = | 15080.0 | nM | 4.82 |
| CHEMBL3261713 | — | IC50 | = | 15350.0 | nM | 4.81 |
| CHEMBL3261712 | — | IC50 | = | 16520.0 | nM | 4.78 |
| CHEMBL3261716 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL561643 | MANGOSTANIN | IC50 | = | 26170.0 | nM | 4.58 |
| CHEMBL3261710 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL3261715 | — | IC50 | = | 40990.0 | nM | 4.39 |
| CHEMBL3261711 | — | IC50 | = | 95830.0 | nM | 4.02 |
| CHEMBL463293 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3261714 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3261717 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3261718 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL464119 | — | IC50 | > | 100000.0 | nM | - |