Assay Detail
Binding
CHEMBL3266784
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Inhibition of equine serum BChE by Ellman's method
19
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.90 | 7.22 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.22 |
| CHEMBL3262489 | — | — | 2 | 7.11 |
| CHEMBL3262479 | — | — | 1 | 6.06 |
| CHEMBL3262487 | — | — | 1 | 5.99 |
| CHEMBL3262490 | — | — | 1 | 5.67 |
| CHEMBL2171768 | — | — | 1 | 5.57 |
| CHEMBL3262488 | — | — | 1 | 5.40 |
| CHEMBL81925 | — | — | 1 | 5.33 |
| CHEMBL3262480 | — | — | 1 | 4.71 |
| CHEMBL3262481 | — | — | 1 | - |
| CHEMBL3262482 | — | — | 1 | - |
| CHEMBL3262483 | — | — | 1 | - |
| CHEMBL3262484 | — | — | 1 | - |
| CHEMBL3262485 | — | — | 1 | - |
| CHEMBL3262486 | — | — | 1 | - |
| CHEMBL3262491 | — | — | 1 | - |
| CHEMBL3262492 | — | — | 1 | - |
| CHEMBL2171793 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3262489 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3262479 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL3262487 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL3262490 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL2171768 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL3262488 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL81925 | — | IC50 | = | 4620.0 | nM | 5.33 |
| CHEMBL3262480 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL2171793 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3262492 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3262491 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3262486 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3262485 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3262484 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3262483 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3262482 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3262481 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3262489 | — | Inhibition | - | % | - |