Assay Detail
Binding
CHEMBL3267356
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Inhibition of rat recombinant adenosine receptor A2a
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Adenosine A2A receptor as a drug discovery target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.58 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16687 | CGS-15943 | — | 1 | 9.40 |
| CHEMBL184309 | — | — | 1 | 8.40 |
| CHEMBL413079 | — | — | 1 | 8.30 |
| CHEMBL183181 | — | — | 1 | 7.92 |
| CHEMBL25964 | — | — | 1 | 7.27 |
| CHEMBL426738 | — | — | 1 | 7.20 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16687 | CGS-15943 | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL184309 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL413079 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL183181 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL25964 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL426738 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 25000.0 | nM | 4.60 |