Assay Detail
Binding
CHEMBL3267500
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BuChE in equine serum using butylthiocholine iodide as substrate by Ellman's method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro evaluation of anti-inflammatory activity of ester and amine derivatives of indoline in RAW 264.7 and peritoneal macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.89 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3217012 | — | — | 1 | 6.70 |
| CHEMBL2181475 | — | — | 1 | 6.52 |
| CHEMBL3263347 | — | — | 1 | 6.51 |
| CHEMBL2177716 | — | — | 1 | 6.16 |
| CHEMBL3263351 | — | — | 1 | 6.05 |
| CHEMBL3263349 | — | — | 1 | 5.92 |
| CHEMBL3263348 | — | — | 1 | 5.66 |
| CHEMBL2177708 | — | — | 1 | 5.41 |
| CHEMBL3263352 | — | — | 1 | 5.37 |
| CHEMBL3263350 | — | — | 1 | 5.33 |
| CHEMBL2177718 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3217012 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2181475 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3263347 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2177716 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3263351 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3263349 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3263348 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2177708 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3263352 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL3263350 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2177718 | — | IC50 | = | 6780.0 | nM | 5.17 |