Assay Detail
Functional
CHEMBL3267800
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinvasive activity in human DU145 cells assessed as inhibition of HGF-induced cell motility preincubated for 1 hr before HGF treatment measured after 24 hrs by cell scattering assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Biological Evaluation of Novel Dual EGFR/c-Met Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.33 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460702 | BMS-777607 | 2.0 | 1 | 6.70 |
| CHEMBL3263964 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460702 | BMS-777607 | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3263964 | — | IC50 | = | 1100.0 | nM | 5.96 |