Assay Detail
Binding
CHEMBL3268017
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Inhibition of c-Met (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel type II c-Met inhibitors based on BMS-777607.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.30 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 9.40 |
| CHEMBL524364 | — | — | 1 | 8.70 |
| CHEMBL3260969 | — | — | 1 | 7.57 |
| CHEMBL3989914 | GLESATINIB | 2.0 | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL524364 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3260969 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3989914 | GLESATINIB | IC50 | = | 29.0 | nM | 7.54 |