Compound Detail
CHEMBL3260969
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CCn1cnc(-c2cc3nccc(Oc4ccc(NC(=S)N5CCN(c6ccc(F)cc6)C5=O)cc4F)c3s2)c1
Basic Information
| ChEMBL ID | CHEMBL3260969 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WWJYHVSOOPPZAQ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
576.6
MW (Da)
6.89
ALogP
7
HBA
1
HBD
75.5
PSA (Ų)
0.22
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 7.57 | 7.57 | 27.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 27.0 | nM | 7.57 | Inhibition of c-Met (unknown origin) | 24792774 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24792774 | 10.1016/j.ejmech.2014.04.056 | Hepatocyte growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine