Assay Detail
Binding
CHEMBL3268115
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [20-3H]PDBu from GST-tagged mouse PKC-delta C1B domain N7R mutant expressed in Escherichia coli after 2 to 30 mins by polyethylene glycol precipitation assay in presence of phosphatidylserine
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C ζ and ι from typical C1 domains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.48 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3262941 | — | — | 1 | 9.22 |
| CHEMBL3262942 | — | — | 1 | 9.15 |
| CHEMBL3262940 | — | — | 1 | 9.05 |
| CHEMBL27768 | — | — | 1 | 8.93 |
| CHEMBL380645 | — | — | 1 | 8.70 |
| CHEMBL206889 | — | — | 1 | 8.61 |
| CHEMBL209308 | — | — | 1 | 8.48 |
| CHEMBL3262939 | — | — | 1 | 6.92 |
| CHEMBL3262938 | — | — | 1 | 6.55 |
| CHEMBL3262935 | — | — | 1 | 6.33 |
| CHEMBL3262933 | — | — | 1 | 6.19 |
| CHEMBL3262934 | — | — | 1 | 6.10 |
| CHEMBL3262943 | — | — | 1 | 6.09 |
| CHEMBL3262937 | — | — | 1 | 6.06 |
| CHEMBL3262936 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3262941 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL3262942 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL3262940 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL27768 | — | Ki | = | 1.18 | nM | 8.93 |
| CHEMBL380645 | — | Ki | = | 1.99 | nM | 8.70 |
| CHEMBL206889 | — | Ki | = | 2.48 | nM | 8.61 |
| CHEMBL209308 | — | Ki | = | 3.29 | nM | 8.48 |
| CHEMBL3262939 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3262938 | — | Ki | = | 281.0 | nM | 6.55 |
| CHEMBL3262935 | — | Ki | = | 473.0 | nM | 6.33 |
| CHEMBL3262933 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL3262934 | — | Ki | = | 787.0 | nM | 6.10 |
| CHEMBL3262943 | — | Ki | = | 806.0 | nM | 6.09 |
| CHEMBL3262937 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL3262936 | — | Ki | = | 1737.0 | nM | 5.76 |