Compound Detail
CHEMBL3262934
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Basic Information
| ChEMBL ID | CHEMBL3262934 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WUQHQCHBJVBKAR-GIJQJNRQSA-N |
2
Targets
7
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
418.5
MW (Da)
3.31
ALogP
6
HBA
2
HBD
110.1
PSA (Ų)
0.47
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 6 meas. best 6.15
Kd 1 meas. best 6.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C delta type CHEMBL2560 | Kd | 6.25 | 6.25 | 560.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 6.15 | 5.784 | 710.0 | 5 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C delta type | Kd | = | 560.0 | nM | 6.25 | Displacement of [20-3H]PDBu from GST-tagged full-length mouse PKC-delta C1B doma... | 24684293 |
| Unchecked | Ki | = | 710.0 | nM | 6.15 | Displacement of [20-3H]PDBu from GST-tagged mouse PKC-delta C1B domain P11R muta... | 24684293 |
| Unchecked | Ki | = | 787.0 | nM | 6.1 | Displacement of [20-3H]PDBu from GST-tagged mouse PKC-delta C1B domain N7R mutan... | 24684293 |
| Unchecked | Ki | = | 813.0 | nM | 6.09 | Displacement of [20-3H]PDBu from GST-tagged mouse PKC-delta C1B domain S10R muta... | 24684293 |
| Unchecked | Ki | = | 3800.0 | nM | 5.42 | Displacement of [20-3H]PDBu from GST-tagged mouse PKC-delta C1B domain N7R/P11R ... | 24684293 |
| Unchecked | Ki | = | 6900.0 | nM | 5.16 | Displacement of [20-3H]PDBu from GST-tagged mouse PKC-delta C1B domain L20R muta... | 24684293 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24684293 | 10.1021/jm500165n | Unchecked | 16 |
| 24684293 | 10.1021/jm500165n | Protein kinase C delta type | 1 |
Data from ChEMBL 36 via Core Engine