Assay Detail
Binding
CHEMBL3268116
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [20-3H]PDBu from GST-tagged mouse PKC-delta C1B domain S10R mutant expressed in Escherichia coli after 2 to 30 mins by polyethylene glycol precipitation assay in presence of phosphatidylserine
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C ζ and ι from typical C1 domains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.51 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27768 | — | — | 1 | 9.49 |
| CHEMBL3262941 | — | — | 1 | 9.22 |
| CHEMBL3262942 | — | — | 1 | 9.22 |
| CHEMBL380645 | — | — | 1 | 8.93 |
| CHEMBL3262940 | — | — | 1 | 8.82 |
| CHEMBL206889 | — | — | 1 | 8.68 |
| CHEMBL209308 | — | — | 1 | 8.63 |
| CHEMBL3262939 | — | — | 1 | 7.03 |
| CHEMBL3262938 | — | — | 1 | 6.33 |
| CHEMBL3262935 | — | — | 1 | 6.30 |
| CHEMBL3262937 | — | — | 1 | 6.18 |
| CHEMBL3262934 | — | — | 1 | 6.09 |
| CHEMBL3262933 | — | — | 1 | 6.08 |
| CHEMBL3262943 | — | — | 1 | 5.95 |
| CHEMBL3262936 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27768 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL3262941 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL3262942 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL380645 | — | Ki | = | 1.18 | nM | 8.93 |
| CHEMBL3262940 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL206889 | — | Ki | = | 2.08 | nM | 8.68 |
| CHEMBL209308 | — | Ki | = | 2.33 | nM | 8.63 |
| CHEMBL3262939 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL3262938 | — | Ki | = | 468.0 | nM | 6.33 |
| CHEMBL3262935 | — | Ki | = | 496.0 | nM | 6.30 |
| CHEMBL3262937 | — | Ki | = | 667.0 | nM | 6.18 |
| CHEMBL3262934 | — | Ki | = | 813.0 | nM | 6.09 |
| CHEMBL3262933 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL3262943 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL3262936 | — | Ki | = | 1765.0 | nM | 5.75 |