Assay Detail
Binding
CHEMBL3268117
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [20-3H]PDBu from GST-tagged mouse PKC-delta C1B domain P11R mutant expressed in Escherichia coli after 2 to 30 mins by polyethylene glycol precipitation assay in presence of phosphatidylserine
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C ζ and ι from typical C1 domains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.38 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3262941 | — | — | 1 | 9.00 |
| CHEMBL27768 | — | — | 1 | 8.92 |
| CHEMBL3262942 | — | — | 1 | 8.92 |
| CHEMBL380645 | — | — | 1 | 8.83 |
| CHEMBL3262940 | — | — | 1 | 8.77 |
| CHEMBL206889 | — | — | 1 | 8.63 |
| CHEMBL209308 | — | — | 1 | 7.98 |
| CHEMBL3262938 | — | — | 1 | 7.00 |
| CHEMBL3262939 | — | — | 1 | 6.92 |
| CHEMBL3262933 | — | — | 1 | 6.38 |
| CHEMBL3262934 | — | — | 1 | 6.15 |
| CHEMBL3262935 | — | — | 1 | 6.03 |
| CHEMBL3262937 | — | — | 1 | 6.00 |
| CHEMBL3262943 | — | — | 1 | 5.69 |
| CHEMBL3262936 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3262941 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL27768 | — | Ki | = | 1.19 | nM | 8.92 |
| CHEMBL3262942 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL380645 | — | Ki | = | 1.48 | nM | 8.83 |
| CHEMBL3262940 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL206889 | — | Ki | = | 2.32 | nM | 8.63 |
| CHEMBL209308 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL3262938 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3262939 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3262933 | — | Ki | = | 421.0 | nM | 6.38 |
| CHEMBL3262934 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL3262935 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL3262937 | — | Ki | = | 998.0 | nM | 6.00 |
| CHEMBL3262943 | — | Ki | = | 2030.0 | nM | 5.69 |
| CHEMBL3262936 | — | Ki | = | 3360.0 | nM | 5.47 |