Assay Detail
Binding
CHEMBL3268713
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Inhibition of Syk in anti IgM-stimulated human Ramos cells assessed as BLNK phosphorylation by cellular assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Ramos |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Syk inhibitors with high potency in presence of blood.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.77 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3262616 | — | — | 1 | 7.46 |
| CHEMBL3262620 | — | — | 1 | 7.43 |
| CHEMBL3262357 | — | — | 1 | 7.33 |
| CHEMBL3262624 | — | — | 1 | 7.26 |
| CHEMBL3262617 | — | — | 1 | 7.22 |
| CHEMBL3262622 | — | — | 1 | 7.11 |
| CHEMBL3262356 | — | — | 1 | 7.05 |
| CHEMBL3262625 | — | — | 1 | 7.02 |
| CHEMBL2177736 | — | — | 1 | 6.75 |
| CHEMBL3262618 | — | — | 1 | 6.68 |
| CHEMBL3262623 | — | — | 1 | 6.55 |
| CHEMBL3262358 | — | — | 1 | 6.50 |
| CHEMBL3262619 | — | — | 1 | 6.42 |
| CHEMBL475251 | R-406 | 2.0 | 1 | 6.34 |
| CHEMBL3262355 | — | — | 1 | 6.11 |
| CHEMBL3262359 | — | — | 1 | 5.03 |
| CHEMBL3262621 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3262616 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3262620 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3262357 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3262624 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3262617 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3262622 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3262356 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3262625 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL2177736 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL3262618 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL3262623 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL3262358 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3262619 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL475251 | R-406 | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL3262355 | — | IC50 | = | 778.0 | nM | 6.11 |
| CHEMBL3262359 | — | IC50 | = | 9274.0 | nM | 5.03 |
| CHEMBL3262621 | — | IC50 | - | — | - |