Compound Detail
CHEMBL3262359
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Basic Information
| ChEMBL ID | CHEMBL3262359 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZOWLYZDDVZVMPV-LSDHHAIUSA-N |
1
Targets
2
Activities
1
Assay Types
1
PK Parameters
7
Publications
0
Known Names
Molecular Properties
403.5
MW (Da)
3.24
ALogP
7
HBA
4
HBD
113.7
PSA (Ų)
0.42
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK CHEMBL2599 | IC50 | 5.8 | 5.415 | 1600.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.15 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK | IC50 | = | 1600.0 | nM | 5.8 | Inhibition of Syk (unknown origin) using 4 uM peptide assessed as product format... | 24726806 |
| Tyrosine-protein kinase SYK | IC50 | = | 9274.0 | nM | 5.03 | Inhibition of Syk in anti IgM-stimulated human Ramos cells assessed as BLNK phos... | 24726806 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24726806 | 10.1016/j.bmcl.2014.03.075 | Tyrosine-protein kinase SYK | 3 |
| 24726806 | 10.1016/j.bmcl.2014.03.075 | Tyrosine-protein kinase Lyn | 1 |
| 24726806 | 10.1016/j.bmcl.2014.03.075 | Tyrosine-protein kinase ZAP-70 | 1 |
| 24726806 | 10.1016/j.bmcl.2014.03.075 | Tyrosine-protein kinase JAK2 | 1 |
| 24726806 | 10.1016/j.bmcl.2014.03.075 | Bone marrow cell | 1 |
| 24726806 | 10.1016/j.bmcl.2014.03.075 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 24726806 | 10.1016/j.bmcl.2014.03.075 | Liver microsome | 1 |
Data from ChEMBL 36 via Core Engine