Assay Detail
Functional
CHEMBL3268918
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against trypomastigotes of Trypanosoma cruzi CA-I/72 infected in mouse C2C12 cells after 72 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | C2C12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 9.24 | 10.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3259946 | — | — | 1 | 10.77 |
| CHEMBL3259944 | — | — | 1 | 9.92 |
| CHEMBL3259948 | — | — | 1 | 9.33 |
| CHEMBL3259949 | — | — | 1 | 9.22 |
| CHEMBL3259945 | — | — | 1 | 8.89 |
| CHEMBL3259947 | — | — | 1 | 8.54 |
| CHEMBL3259950 | — | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3259946 | — | EC50 | = | 0.017 | nM | 10.77 |
| CHEMBL3259944 | — | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL3259948 | — | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL3259949 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3259945 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3259947 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3259950 | — | EC50 | = | 9.2 | nM | 8.04 |