Assay Detail
Binding
CHEMBL3270404
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Inhibition of ovine COX1 using arachidonic acid as substrate preincubated for 10 mins before substrate addition measured after 5 mins by EIA
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 4.93 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.75 |
| CHEMBL3262708 | — | — | 1 | 4.82 |
| CHEMBL3262706 | — | — | 1 | 4.76 |
| CHEMBL3262712 | — | — | 1 | 4.65 |
| CHEMBL3262710 | — | — | 1 | 4.61 |
| CHEMBL508681 | NEPODIN | — | 1 | 4.56 |
| CHEMBL41092 | CHRYSOPHANOL | — | 1 | 4.33 |
| CHEMBL3262453 | — | — | 1 | - |
| CHEMBL3262698 | — | — | 1 | - |
| CHEMBL3262709 | — | — | 1 | - |
| CHEMBL3262707 | — | — | 1 | - |
| CHEMBL3262705 | — | — | 1 | - |
| CHEMBL3262704 | — | — | 1 | - |
| CHEMBL3262703 | — | — | 1 | - |
| CHEMBL3262702 | — | — | 1 | - |
| CHEMBL3262701 | — | — | 1 | - |
| CHEMBL3262700 | — | — | 1 | - |
| CHEMBL3262699 | — | — | 1 | - |
| CHEMBL3262713 | — | — | 1 | - |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | - |
| CHEMBL3262721 | — | — | 1 | - |
| CHEMBL3262720 | — | — | 1 | - |
| CHEMBL3262719 | — | — | 1 | - |
| CHEMBL3262718 | — | — | 1 | - |
| CHEMBL3262711 | — | — | 1 | - |
| CHEMBL3262716 | — | — | 1 | - |
| CHEMBL3262715 | — | — | 1 | - |
| CHEMBL3262714 | — | — | 1 | - |
| CHEMBL289530 | — | — | 1 | - |
| CHEMBL3262717 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3262708 | — | IC50 | = | 15210.0 | nM | 4.82 |
| CHEMBL3262706 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL3262712 | — | IC50 | = | 22230.0 | nM | 4.65 |
| CHEMBL3262710 | — | IC50 | = | 24470.0 | nM | 4.61 |
| CHEMBL508681 | NEPODIN | IC50 | = | 27430.0 | nM | 4.56 |
| CHEMBL41092 | CHRYSOPHANOL | IC50 | = | 46210.0 | nM | 4.33 |
| CHEMBL3262453 | — | IC50 | - | — | - | |
| CHEMBL3262697 | — | IC50 | - | — | - | |
| CHEMBL3262709 | — | IC50 | - | — | - | |
| CHEMBL3262707 | — | IC50 | - | — | - | |
| CHEMBL3262705 | — | IC50 | - | — | - | |
| CHEMBL3262704 | — | IC50 | - | — | - | |
| CHEMBL3262703 | — | IC50 | - | — | - | |
| CHEMBL3262702 | — | IC50 | - | — | - | |
| CHEMBL3262701 | — | IC50 | - | — | - | |
| CHEMBL3262700 | — | IC50 | - | — | - | |
| CHEMBL3262699 | — | IC50 | - | — | - | |
| CHEMBL3262698 | — | IC50 | - | — | - | |
| CHEMBL3262713 | — | IC50 | - | — | - | |
| CHEMBL118 | CELECOXIB | IC50 | > | 30000.0 | nM | - |
| CHEMBL3262721 | — | IC50 | - | — | - | |
| CHEMBL3262720 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3262719 | — | IC50 | - | — | - | |
| CHEMBL3262718 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3262711 | — | IC50 | - | — | - | |
| CHEMBL3262716 | — | IC50 | - | — | - | |
| CHEMBL3262715 | — | IC50 | - | — | - | |
| CHEMBL3262714 | — | IC50 | - | — | - | |
| CHEMBL289530 | — | IC50 | - | — | - | |
| CHEMBL3262717 | — | IC50 | > | 30000.0 | nM | - |