Assay Detail
Binding
CHEMBL3270595
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Inhibition of full length human wild type his-tagged BTK expressed in Sf9 cells using biotinylated peptide as substrate after 1 hr by Fluorescence assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.06 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3263640 | — | — | 1 | 8.10 |
| CHEMBL3263634 | — | — | 1 | 7.77 |
| CHEMBL3263656 | — | — | 1 | 7.75 |
| CHEMBL3263639 | — | — | 1 | 7.72 |
| CHEMBL3263632 | — | — | 1 | 7.60 |
| CHEMBL3263648 | — | — | 1 | 7.58 |
| CHEMBL3263658 | — | — | 1 | 7.57 |
| CHEMBL3263633 | — | — | 1 | 7.55 |
| CHEMBL3263649 | — | — | 1 | 7.50 |
| CHEMBL3263646 | — | — | 1 | 7.48 |
| CHEMBL3263655 | — | — | 1 | 7.46 |
| CHEMBL3263628 | — | — | 1 | 7.42 |
| CHEMBL3263659 | — | — | 1 | 7.39 |
| CHEMBL3263636 | — | — | 1 | 7.37 |
| CHEMBL3263650 | — | — | 1 | 7.32 |
| CHEMBL3263657 | — | — | 1 | 7.31 |
| CHEMBL3263631 | — | — | 1 | 7.19 |
| CHEMBL3263647 | — | — | 1 | 7.19 |
| CHEMBL3263314 | — | — | 1 | 7.17 |
| CHEMBL3263654 | — | — | 1 | 7.11 |
| CHEMBL3263651 | — | — | 1 | 7.08 |
| CHEMBL3263637 | — | — | 1 | 7.06 |
| CHEMBL3263653 | — | — | 1 | 6.96 |
| CHEMBL3263638 | — | — | 1 | 6.90 |
| CHEMBL3263642 | — | — | 1 | 6.85 |
| CHEMBL3263635 | — | — | 1 | 6.84 |
| CHEMBL3263313 | — | — | 1 | 6.82 |
| CHEMBL3263652 | — | — | 1 | 6.77 |
| CHEMBL3263641 | — | — | 1 | 6.77 |
| CHEMBL3263629 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3263640 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3263634 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3263656 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3263639 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3263632 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3263648 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3263658 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3263633 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3263649 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3263646 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3263655 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3263628 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3263659 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3263636 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3263650 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3263657 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3263631 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3263647 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3263314 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3263654 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3263651 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3263637 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL3263653 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL3263638 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL3263642 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3263635 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL3263313 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3263641 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3263652 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL3263629 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL3263630 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL3263645 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL3263315 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL3263644 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3263643 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3263317 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3263316 | — | IC50 | > | 50000.0 | nM | - |