Compound Detail
CHEMBL3263654
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3263654 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AOGMMPLPRHJTED-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
429.5
MW (Da)
3.13
ALogP
7
HBA
3
HBD
122.0
PSA (Ų)
0.43
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK CHEMBL5251 | IC50 | 7.11 | 7.11 | 77.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK | IC50 | = | 77.0 | nM | 7.11 | Inhibition of full length human wild type his-tagged BTK expressed in Sf9 cells ... | 24685542 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24685542 | 10.1016/j.bmcl.2014.02.075 | Unchecked | 5 |
| 24685542 | 10.1016/j.bmcl.2014.02.075 | Tyrosine-protein kinase BTK | 1 |
Data from ChEMBL 36 via Core Engine